Cosalane

Overview

Cosalane (NSC 658586) is a CCR7 ( IC 50 = 2.43 μM) and CXCR2 antagonist ( IC 50 = 0.66 μM). Cosalane is an inhibitor of HIV replication with a wide range of activity against HIV-1 isolates, HIV-2 , Rauscher murine leukemia virus, HSV-1 , HSV-2 and human cytomegalovirus. Cosalane inhibits both attachment of gp120 to CD4 . Cosalane inhibits human and murine CCR7 in response to both CCL19 and CCL21 agonists. Cosalane can be studied in research for HIV or attenuating acute graft-versus-host disease (aGVHD) in allogeneic hematopoietic stem cell transplantation (HSCT).

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Infection | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Signaling Pathways > CCR | Products > Signaling Pathways > CXCR | Products > Signaling Pathways > HIV | Products > Signaling Pathways > HSV

Product Information

• Catalog No.: HY-120427
• CAS No.: 154212-56-3
• Molecular Formula: C45H60Cl2O6
• Molecular Weight: 767.86
• Purity: 99.50%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (3.26 mM); Clear solution
• Availability: In-stock

Source

Original product source