WB403

Overview

WB403 is an orally active TGR5 activator with an EC 50 of 5.5 μM against human TGR5 . WB403 activates TGR5 to stimulate downstream signaling pathways, promote GLP-1 secretion, improve glucose tolerance in mice with type 2 diabetes, and reduce levels of fasting blood glucose, postprandial blood glucose and HbA1c . WB403 increases pancreatic β-cell mass and restores the distribution of α-cells and β-cells in islets. WB403 is applicable to the research of type 2 diabetes.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Glucose Metabolism | Products > Disease Areas > Type 2 Diabetes | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > G protein-coupled Bile Acid Receptor 1

Product Information

• Catalog No.: HY-120565
• CAS No.: 1594041-84-5
• Molecular Formula: C19H19BrN2OS
• Molecular Weight: 403.34
• Purity: 99.16%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1 mg/mL (2.48 mM); Clear solution
• Availability: In-stock

Source

Original product source