Sibiriline

Overview

Sibiriline is a specific competitive inhibitor of RIPK1 that targets the RIPK1 ATP-binding site and locks it in an inactive conformation. Sibiriline inhibits TNF-induced RIPK1 -dependent necroptosis and RIPK1 -dependent apoptosis , but does not protect cells from caspase-dependent apoptosis . Sibiriline protects mice from concanavalin A-induced hepatitis and has the potential to inhibit immune-dependent hepatitis..

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Necroptosis | Products > Signaling Pathways > RIP kinase | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-120600
• CAS No.: 1346526-26-8
• Molecular Formula: C13H10N2O
• Molecular Weight: 210.23
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source