BMS-284640

Overview

BMS-284640 is a synthetic sodium hydrogen exchange isomer-1 ( NHE -1) inhibitor. BMS-284640 has a more than 380-fold higher NHE -1 inhibitory activity (IC50: 9 nM) compared to cariporide ( HY-19693 ) and is more selective for NHE -1 over NHE -2 (IC50: 1.8 μM) and NHE -5 (IC50: 3.36 μM). BMS-284640 and its analogs also exhibit enhanced oral bioavailability and prolonged plasma half-life in rats..

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Na+/H+ Exchanger (NHE)

Product Information

• Catalog No.: HY-120623
• CAS No.: 230640-88-7
• Molecular Formula: C15H19N3O2
• Molecular Weight: 273.33
• Purity: 99.75%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 2.5 mg/mL (9.15 mM); Clear solution
• Availability: In-stock

Source

Original product source