BPIQ-II hydrochloride

Overview

BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor ( EGFR ; IC 50 =8 pM). It is selective for EGFR over an assortment of other tyrosine and serine/threonine kinases. Cellular studies indicate that BPIQ-II can enter cells and very selectively shut down EGF-stimulated signal transmission by binding competitively at the ATP site of EGFR .

Application

Products | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Others | Products > Signaling Pathways > EGFR

Product Information

• Catalog No.: HY-120857
• CAS No.: 171179-37-6
• Molecular Formula: C15H11BrClN5
• Molecular Weight: 376.64
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source