CXCR2-IN-2

Overview

CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist ( IC 50 =5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC 50 of 0.04 μM.

Application

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Product Information

• Catalog No.: HY-120878
• CAS No.: 1838123-21-9
• Molecular Formula: C18H23ClN2O5S
• Molecular Weight: 414.90
• Purity: 99.52%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 6 mg/mL (14.46 mM); Clear solution
• Availability: In-stock

Source

Original product source