Poloxipan

Overview

Poloxipan is a pan-specific polo-like kinase ( PLK ) inhibitor that can inhibit a non-catalytic region at the C-terminus called the Polo-box domain ( PBD ) found in kinases. The IC 50 values for Poloxipan against the PBDs of PLK-1/2/3 are 3.2 μM, 1.7 μM, and 3.0 μM, respectively. Poloxipan also inhibits other phospho-tyrosine binding domains, such as the forkhead-associated (FHA) domain of CHK-2 , the WW domain of peptidyl-prolyl cis/trans isomerase ( PIN1 ), and the phospho-tyrosine binding domains of STAT1/3/5 and lymphocyte-specific protein tyrosine kinase's SH2 domain. Poloxipan can be used in cancer research.

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > JAK/STAT Signaling | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > Polo-like Kinase (PLK) | Products > Signaling Pathways > PIN1 | Products > Signaling Pathways > STAT

Product Information

• Catalog No.: HY-12135
• CAS No.: 1239513-63-3
• Molecular Formula: C14H10BrN3O3S
• Molecular Weight: 380.22
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source