DAP-81

CAS No.：794466-17-4
Grade：99.98%
Formula：C25H20N6O4
M.W.：468.46

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

DAP-81 is an inhibitory agent targeting Polo-like kinases (Plks), a class of evolutionarily conserved serine/threonine kinases. DAP-81 dose-dependently increases the number of monopolar spindles in treated cells. High-resolution live-cell microscopy revealed that Plk activity is required for the assembly and maintenance of bipolar mitotic spindles. Plk inhibition destabilizes centromeric microtubules while stabilizing other spindle microtubules, leading to the formation of monopolar spindles. Further testing of compounds based on "privileged scaffolds" such as the DAP scaffold may lead to the discovery of new cell division probes and anti-microtubule agents.

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Others | Products > Signaling Pathways > Polo-like Kinase (PLK)

Product Information

Catalog No.: HY-121634
CAS No.: 794466-17-4
Molecular Formula: C25H20N6O4
Molecular Weight: 468.46
Purity: 99.98%
Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source

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