Akuammine

Overview

Akuammine is an indole alkaloid that has been found in Picralima nitida and has analgesic activity. It selectively binds to the μ- and κ-opioid receptors over the δ-opioid receptor (Kis=0.3, 1.68, and 10.4 μM for the human receptors, respectively). Akuammine inhibits forskolin-induced cAMP production in HEK293 cells expressing human μ- or κ-opioid receptors ( IC 50 s=2.6 and 0.073 μM, respectively). It increases the latency to withdrawal in the tail-flick or hot plate test in mice when administered at a dose of 60 mg/kg.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Research Areas > Neurological Disease

Product Information

• Catalog No.: HY-122189
• CAS No.: 3512-87-6
• Molecular Formula: C22H26N2O4
• Molecular Weight: 382.45
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source