PCS1055 dihydrochloride

Overview

PCS1055 dihydrochloride is a potent, selective and competitive muscarinic M4 receptor antagonist with an IC 50 of 18.1 nM and a K d of 5.72 nM. PCS1055 dihydrochloride inhibits radioligand [ 3 H]-NMS binding to the M4 receptor with a K i of 6.5 nM. PCS1055 dihydrochloride exhibits >100-fold selectivity over M1-, M3-, and M5-receptors and 30-fold selectivity at the M2 receptor. PCS1055 dihydrochloride is also a potent AChE inhibitor with IC 50 s of 22 nM and 120 nM for electric eel and human AChE , respectively.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Parkinson's Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > mAChR | Products > Signaling Pathways > Cholinesterase (ChE)

Product Information

• Catalog No.: HY-122203
• CAS No.: 361979-40-0
• Molecular Formula: C27H34Cl2N4
• Molecular Weight: 485.49
• Purity: 98.88%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (5.15 mM); Clear solution
• Availability: In-stock

Source

Original product source