P53R3

Overview

P53R3 is a potent p53 reactivator and restores sequence-specific DNA binding of p53 hot spot mutants, including p53 R175H , p53 R248W and p53 R273H . P53R3 induces p53-dependent antiproliferative effects with much higher specificity than PRIMA-1. P53R3 enhances the recruitment of wild-type p53 and p53 M237I to several target gene promoters. P53R3 strongly enhances the mRNA , total protein and cell surface expression of the death receptor death receptor 5 (DR5) . P53R3 is used for cancer research.

Application

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Product Information

• Catalog No.: HY-122578
• CAS No.: 922150-12-7
• Molecular Formula: C32H35Cl2N5O2
• Molecular Weight: 592.56
• Purity: 99.93%
• Storage: 4°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Availability: In-stock

Source

Original product source