proMMP-9 inhibitor-3c

Overview

proMMP-9 inhibitor-3c (compound 3c) is a potent proMMP-9 inhibitor. proMMP-9 inhibitor-3c is specific for binding to the proMMP-9 hemopexin-like domain ( K d =320 nM). proMMP-9 inhibitor-3c disruption of MMP-9 homodimerization prevents association of proMMP-9 with both α4β1 integrin and CD44 and results in the dissociation of EGFR . This disruption results in decreased phosphorylation of Src and its downstream target proteins focal adhesion kinase ( FAK ) and paxillin (PAX).

Application

Products | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > MMP | Products > Signaling Pathways > Src | Products > Signaling Pathways > FAK

Product Information

• Catalog No.: HY-122585
• CAS No.: 2138321-18-1
• Molecular Formula: C18H20FN3O2S
• Molecular Weight: 361.43
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source