PF-06273340

Overview

PF-06273340 is a peripherally restricted pan- Trk inhibitor with IC 50 values of 6, 4, 3 nM for TrkA , TrkB , and TrkC receptors. PF-06273340 binds in a DFG-out conformation, targeting less conserved kinase ligand binding domain regions outside the ATP binding pocket. PF-06273340 exhibits anti-hyperalgesic and analgesic effects. PF-06273340 can be used for the research of pain.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Pain | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Trk Receptor

Product Information

• Catalog No.: HY-122616
• CAS No.: 1402438-74-7
• Molecular Formula: C23H22ClN7O3
• Molecular Weight: 479.92
• Purity: 98.8%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source