TH-257

CAS No.：2244678-29-1
Grade：98.36%
Formula：C24H26N2O3S
M.W.：422.54
Solvent：≥ 2.08 mg/mL (4.92 mM); Clear solution

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

TH-257 is a potent inhibitor of LIMK1 and LIMK2 with IC 50 values of 84 nM and 39 nM for LIMK1 and LIMK2 , respectively, and it can be used as a chemical probe for LIMK1 and LIMK2 . TH-257 is an allosteric inhibitor targeting a binding pocket induced by an αC and DFG-out conformation. TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 μM.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > LIM Kinase (LIMK)

Product Information

Catalog No.: HY-122630
CAS No.: 2244678-29-1
Molecular Formula: C24H26N2O3S
Molecular Weight: 422.54
Purity: 98.36%
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
Solubility: ≥ 2.08 mg/mL (4.92 mM); Clear solution
Availability: In-stock

Source

Original product source

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