TH-257

Overview

TH-257 is a potent inhibitor of LIMK1 and LIMK2 with IC 50 values of 84 nM and 39 nM for LIMK1 and LIMK2 , respectively, and it can be used as a chemical probe for LIMK1 and LIMK2 . TH-257 is an allosteric inhibitor targeting a binding pocket induced by an αC and DFG-out conformation. TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 μM.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > LIM Kinase (LIMK)

Product Information

• Catalog No.: HY-122630
• CAS No.: 2244678-29-1
• Molecular Formula: C24H26N2O3S
• Molecular Weight: 422.54
• Purity: 98.36%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.08 mg/mL (4.92 mM); Clear solution
• Availability: In-stock

Source

Original product source