SKLB-C05

Overview

SKLB-C05 is a novel selective, orally active TOPK inhibitor, with an IC 50 of 0.5 nM. SKLB-C05 selectively inhibit TOPK kinase. SKLB-C05 induces Apoptosis , downregulates c-Myc , γ-H2AX , activates p53 , blocks FAK/Src medicated migration-related signaling. SKLB-C05 disturbs cell mitosis . SKLB-C05 shows anticancer activity only against TOPK-positive colorectal cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Src | Products > Signaling Pathways > Mitosis | Products > Signaling Pathways > TOPK | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > c-Myc | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > FAK

Product Information

• Catalog No.: HY-122860
• CAS No.: 2300981-68-2
• Molecular Formula: C23H23ClN2O2
• Molecular Weight: 394.89
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source