HOIPIN-8

Overview

HOIPIN-8 is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) with an IC 50 of 11 nM. HOIPIN-8 is a HOIPIN-1 derivative with enhanced the potency by 255-fold in the petit-LUBAC inhibition, and 10-fold and 4-fold in the LUBAC- and TNF-α-mediated NF-κB activation, respectively than HOIPIN-1. HOIPIN-1 is a promising tool to explore the cellular functions of LUBAC.

Application

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Product Information

• Catalog No.: HY-122882
• CAS No.: 2519537-70-1
• Molecular Formula: C23H15F2N4NaO3
• Molecular Weight: 456.38
• Purity: 98.90%
• Storage: -20°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: 1.25 mg/mL (2.74 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source