Tanshindiol C is a S-adenosylmethionine-competitive EZH2 ( Histone Methyltransferase ) inhibitor with an IC 50 of 0.55 μM for inhibiting the methyltransferase activity. Tanshindiol C is also an activator of both Nrf2 and Sirtuin 1 ( Sirt1 ) in macrophages. Tanshindiol C possesses anti-cancer activity, and can be used for atherosclerosis research.
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