KCN1

Overview

KCN1 is a p300/HIF-1α interaction inhibitor with a K d value of 345 nM for p300-CH1 . KCN1 binds to the CH1 domain of p300, blocks the assembly of the p300/HIF-1α complex, and disrupts the HIF-1α-p300/CBP interaction. KCN1 inhibits cancer cell growth, induces cancer cell cycle arrest and apoptosis . KCN1 inhibits β-galactosidase activity and downregulates the expression of VEGF , Glut1 , CA9 and CAIX . KCN1 exerts anticancer activity in mouse tumor xenograft models. KCN1 can be used in research related to malignant glioma, pancreatic cancer and metastatic uveal melanoma.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Melanoma | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Glioma | Products > Disease Areas > Metastatic Melanoma | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Carbonic Anhydrase | Products > Signaling Pathways > VEGFR | Products > Signaling Pathways > GLUT | Products > Signaling Pathways > HIF/HIF Prolyl-Hydroxylase | Products > Signaling Pathways > Histone Acetyltransferase | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-123009
• CAS No.: 927823-01-6
• Molecular Formula: C26H27NO5S
• Molecular Weight: 465.56
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source