GSK-1482160 (isomer)

Overview

GSK-1482160 isomer is the isomer of GSK-1482160 ( HY-19888 ). GSK-1482160 is an orally active and blood-brain barrier penetrant P2X7 receptor ( P2X7R ) negative allosteric modulator with pIC 50 s of 8.5 (human) and 6.5 (rat). GSK-1482160 reduces the efficacy of ATP at the P2X7 receptor without affecting its affinity, thereby inhibiting the release of IL-1β . GSK-1482160 is an effective radioligand and can be labeled with radioactive isotopes like 11C or 18F to image P2X7R. GSK-1482160 can be used for the studies of chronic joint pain and chronic constriction injury (CCI).

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Others | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Drug Isomer

Product Information

• Catalog No.: HY-123382
• CAS No.: 1695551-19-9
• Molecular Formula: C14H14ClF3N2O2
• Molecular Weight: 334.72
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source