PNU-142586

Overview

PNU-142586 is the major metabolite of Linezolid ( HY-10394 ). PNU-142586 can inhibit the activity of DNA topoisomerase 2-α ( TOP2A ) and DNA topoisomerase 2-β ( TOP2B ). PNU-142586 interferes with DNA replication and transcription by blocking the binding of DNA to TOP2 and inhibiting ATP hydrolysis, ultimately leading to antiproliferative and cytotoxic effects, including mitochondrial dysfunction. PNU-142586 can be used to study Linezolid -induced hematotoxicity and its molecular mechanism.

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Others | Products > Signaling Pathways > Topoisomerase

Product Information

• Catalog No.: HY-123393
• CAS No.: 368891-70-7
• Molecular Formula: C16H20FN3O6
• Molecular Weight: 369.34
• Purity: 97.92%
• Storage: -20°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Availability: In-stock

Source

Original product source