UNC2025 hydrochloride

Overview

UNC2025 hydrochloride is a potent, ATP-competitive, highly orally active and BBB-permeable Mer/Flt3 inhibitor with IC 50 values of 0.74 nM and 0.8 nM, respectively. UNC2025 hydrochloride is >45-fold selectivity for MERTK relative to Axl ( IC 50 = 122 nM; K i = 13.3 nM). UNC2025 hydrochloride exhibits an excellent PK properties, and can be used for the investigation of acute leukemia.

Application

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Product Information

• Catalog No.: HY-12344A
• CAS No.: 2070015-17-5
• Molecular Formula: C28H41ClN6O
• Molecular Weight: 513.12
• Purity: 99.96%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 1 mg/mL (1.95 mM); Clear solution
• Availability: In-stock

Source

Original product source