Lasiokaurin

CAS No.：28957-08-6
Grade：99.68%
Formula：C22H30O7
M.W.：406.47
Solvent：≥ 2.5 mg/mL (6.15 mM); Clear solution

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

Lasiokaurin is an anticancer agent. Lasiokaurin can be isolated from Rabdosia rubescens (Hemsl.) H. Hara . Lasiokaurin inhibits the function of the PDPK1-AKT axis, with a K d value of 75.93 μM for PDPK1. Lasiokaurin inhibits mTOR , STAT3 , MAPK and NF-κB . Lasiokaurin reduces the mRNA and protein expression levels of PLK1 . Lasiokaurin decreases DNA synthesis levels, induces cell Apoptosis , and regulates Autophagy processes. Lasiokaurin inhibits tumor growth in xenograft models. Lasiokaurin can be used in research related to nasopharyngeal carcinoma, triple-negative breast cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Triple-Negative Breast Cancer | Products > Disease Areas > Nasopharyngeal Cancer | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Autophagy | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Polo-like Kinase (PLK) | Products > Signaling Pathways > PDK-1 | Products > Signaling Pathways > Akt | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > STAT | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > DNA/RNA Synthesis | Products > Signaling Pathways > Autophagy

Product Information

Catalog No.: HY-123467
CAS No.: 28957-08-6
Molecular Formula: C22H30O7
Molecular Weight: 406.47
Purity: 99.68%
Storage: -20°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution
Availability: In-stock

Source

Original product source

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