Lasiokaurin

Overview

Lasiokaurin is an anticancer agent. Lasiokaurin can be isolated from Rabdosia rubescens (Hemsl.) H. Hara . Lasiokaurin inhibits the function of the PDPK1-AKT axis, with a K d value of 75.93 μM for PDPK1. Lasiokaurin inhibits mTOR , STAT3 , MAPK and NF-κB . Lasiokaurin reduces the mRNA and protein expression levels of PLK1 . Lasiokaurin decreases DNA synthesis levels, induces cell Apoptosis , and regulates Autophagy processes. Lasiokaurin inhibits tumor growth in xenograft models. Lasiokaurin can be used in research related to nasopharyngeal carcinoma, triple-negative breast cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Triple-Negative Breast Cancer | Products > Disease Areas > Nasopharyngeal Cancer | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Autophagy | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Polo-like Kinase (PLK) | Products > Signaling Pathways > PDK-1 | Products > Signaling Pathways > Akt | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > STAT | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > DNA/RNA Synthesis | Products > Signaling Pathways > Autophagy

Product Information

• Catalog No.: HY-123467
• CAS No.: 28957-08-6
• Molecular Formula: C22H30O7
• Molecular Weight: 406.47
• Purity: 99.68%
• Storage: -20°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution
• Availability: In-stock

Source

Original product source