SNAP8719 free base is a selective α 1D -adrenoceptor antagonist ( pK i = 8.89). SNAP8719 free base shows affinity for the dopamine D 2 -, 5-HT 1A -, and the human clonal α 2a -adrenoceptor , with pK i values of 5.98, 6.47, and <5.0, respectively. SNAP8719 free base causes a concentration-dependent increase in the twitch response.
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