Supinoxin

Overview

Supinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNA helicase (P-p68) and a potent first-in-class anti-cancer agent . Supinoxin interacts with Y593 phosphorylated-p68 and attenuates the nuclear shuttling of β-catenin . Supinoxin induces cell apoptosis and inhibits growth of TNBC cancer cell lines with IC 50 s ranging from 10 nM to 20 nM.

Application

Products | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Triple-Negative Breast Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > DNA/RNA Synthesis | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-123611
• CAS No.: 888478-45-3
• Molecular Formula: C22H24FN5O4
• Molecular Weight: 441.46
• Purity: 99.67%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution
• Availability: In-stock

Source

Original product source