Nitroaspirin

CAS No.：175033-36-0
Grade：98.57%
Formula：C16H13NO7
M.W.：331.28
Solvent：≥ 5 mg/mL (15.09 mM); Clear solution

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

Nitroaspirin (NCX 4016) is an orally active inhibitor of ARG1 and NOS2 . Nitroaspirin reduces ARG1 enzymatic activity via the STAT6 -mediated signaling pathway, and feedback-inhibits the catalytic activity of NOS2 in a NO-releasing group-dependent manner. Nitroaspirin continuously releases intracellular NO, inducing redox-dependent loss of cell viability. Nitroaspirin also exerts anti-angiogenic effects by causing endothelial barrier dysfunction, and effectively inhibits the proliferation of Cisplatin ( HY-17394 )-resistant human ovarian cancer cells . Nitroaspirin can be used in research related to colon cancer , breast cancer and Cisplatin -resistant human ovarian cancer .

Application

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Product Information

Catalog No.: HY-123823
CAS No.: 175033-36-0
Molecular Formula: C16H13NO7
Molecular Weight: 331.28
Purity: 98.57%
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Solubility: ≥ 5 mg/mL (15.09 mM); Clear solution
Availability: In-stock

Source

Original product source

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