Nitroaspirin

Overview

Nitroaspirin (NCX 4016) is an orally active inhibitor of ARG1 and NOS2 . Nitroaspirin reduces ARG1 enzymatic activity via the STAT6 -mediated signaling pathway, and feedback-inhibits the catalytic activity of NOS2 in a NO-releasing group-dependent manner. Nitroaspirin continuously releases intracellular NO, inducing redox-dependent loss of cell viability. Nitroaspirin also exerts anti-angiogenic effects by causing endothelial barrier dysfunction, and effectively inhibits the proliferation of Cisplatin ( HY-17394 )-resistant human ovarian cancer cells . Nitroaspirin can be used in research related to colon cancer , breast cancer and Cisplatin -resistant human ovarian cancer .

Application

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Product Information

• Catalog No.: HY-123823
• CAS No.: 175033-36-0
• Molecular Formula: C16H13NO7
• Molecular Weight: 331.28
• Purity: 98.57%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (15.09 mM); Clear solution
• Availability: In-stock

Source

Original product source