MRK-623 (Compound 14k) is an orally active, high-affinity GABA A receptor agonist, with the K i values of 0.85 nM, 3.7 nM, 4.0 nM, and 0.53 nM for α1, α2, α3, and α5, respectively. MRK-623 shows anxiolytic effect.
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