KPT-6566

Overview

KPT-6566 is a selective and covalent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1 , selectively inhibits and degrades PIN1 . KPT-6566 shows an IC 50 value of 640 nM and a K i value of 625.2 nM for PIN1 PPIase domain . KPT-6566 can be used for the research of cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PIN1

Product Information

• Catalog No.: HY-123847
• CAS No.: 881487-77-0
• Molecular Formula: C22H21NO5S2
• Molecular Weight: 443.54
• Purity: 98.0%
• Storage: 4°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Solubility: 1.92 mg/mL (4.33 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source