Lofepramine

Overview

Lofepramine (Lopramine) is a modified tricyclic and orally active antidepressant. Lofepramine inhibits the uptake of Noradrenaline (NA) ( HY-13715 ) and 5-hydroxytryptamine (5-HT) with IC 50 s of 2.7 μM and 11 μM, respectively. Lofepramine exerts its antidepressant activity by promoting noradrenergic neurotransmission. Lofepramine also enhances serotonergic neurotransmission by inhibiting neuronal uptake of 5-HT and tryptophan pyrrolase. Lofepramine exhibits significant anxiolytic properties. .

Application

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Product Information

• Catalog No.: HY-12390
• CAS No.: 23047-25-8
• Molecular Formula: C26H27ClN2O
• Molecular Weight: 418.96
• Purity: 99.36%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.08 mg/mL (4.96 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source