Raphin1 acetate

Overview

Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B) . Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase ( K d =33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 acetate crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Phosphatase

Product Information

• Catalog No.: HY-123960A
• CAS No.: 2242616-04-0
• Molecular Formula: C10H12Cl2N4O2
• Molecular Weight: 291.13
• Purity: 99.93%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.08 mg/mL (7.14 mM); Clear solution
• Availability: In-stock

Source

Original product source