AZ10397767

Overview

AZ10397767 is an orally active, selective CXCR2 receptor antagonist with an IC 50 of 1 nM. AZ10397767 attenuates the Oxaliplatin ( HY-17371 )-induced NF-κB transcriptional activity and potentiates Oxaliplatin -induced apoptosis in androgen-independent prostate cancer (AIPC) cells. AZ10397767 significantly inhibits neutrophil recruitment into tumors which then adversely affects tumor growth in vitro and in vivo.

Application

Products | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > CXCR

Product Information

• Catalog No.: HY-124056
• CAS No.: 333742-63-5
• Molecular Formula: C15H14ClFN4O2S2
• Molecular Weight: 400.88
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source