SMK-17

Overview

SMK-17 is a selective, non-ATP-competitive MEK1/MEK2 inhibitor with IC 50 s of 62 nM and 56 nM, respectively. SMK-17 binds to the allosteric pocket of MEK1/2. SMK-17 induces apoptosis in tumor cell lines harboring β-catenin mutations.

Application

Products | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > MEK | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-12447
• CAS No.: 765958-29-0
• Molecular Formula: C20H24ClF2IN4O2S
• Molecular Weight: 584.85
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source