TC-2153 is a selective inhibitor of striatal-enriched protein tyrosine phosphatase ( STEP ), with psychotropic activity and low acute toxicity. TC-2153 increases the expression of brain-derived neurotropic factor ( BDNF ) in the brain. And it decreases MAOA and 5-HT1A receptor s mRNA level in midbrain. TC-2153 also inhibits 5-HT2A receptor -mediated signaling.
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