WS3

Overview

WS3 is an allosteric inhibitor of 14-3-3 ( 14-3-3ζ : K d = 2.29 μM). WS3 activates GSK3β by disrupting the binding of 14-3-3-pGSK3β , promotes the ubiquitination and degradation of NRF2 , and inhibits the NRF2-ARE signaling pathway ( IC 50 = 135 nM). It exerts antioxidant inhibition and chemotherapeutic/ferroptosis sensitizing effects in tumors with hyperactivated NRF2. WS3 binds to EBP1/IKKε and promotes the proliferation of β cells and retinal pigment epithelial (RPE) cells, which can be applied to islet regeneration and RPE expansion transplantation . WS3 is applicable to research related to age-related macular degeneration, retinal degeneration and non-small cell lung cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Glucose Metabolism | Products > Disease Areas > Non-Small Cell Lung Cancer | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > IKK | Products > Signaling Pathways > 14-3-3 Protein | Products > Signaling Pathways > GSK-3 | Products > Signaling Pathways > Keap1-Nrf2

Product Information

• Catalog No.: HY-12462
• CAS No.: 1421227-52-2
• Molecular Formula: C28H30F3N7O3
• Molecular Weight: 569.58
• Purity: 98.70%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: 3.33 mg/mL (5.85 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source