PZ-2891

Overview

PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase ( PANK ) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC 50 s of 40.2 nM, 0.7 nM and 1.3 nM, respectively.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > PANK

Product Information

• Catalog No.: HY-124634
• CAS No.: 2170608-82-7
• Molecular Formula: C20H23N5O
• Molecular Weight: 349.43
• Purity: 99.68%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (7.15 mM); Clear solution
• Availability: In-stock

Source

Original product source