D-I03

Overview

D-I03 is a selective RAD52 inhibitor with a K d of 25.8 μM. D-I03 specifically inhibits RAD52 -dependent single-strand annealing (SSA) and D-loop formation with IC 50 s of 5 μM and 8 μM, respectively. D-I03 suppresses growth of BRCA1- and BRCA2-deficient cells and inhibits formation of damage-induced RAD52 foci, but does not effect on RAD51 foci induced by Cisplatin.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-124691
• CAS No.: 688342-78-1
• Molecular Formula: C23H36N6S
• Molecular Weight: 428.64
• Purity: 99.70%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (5.83 mM); Clear solution
• Availability: In-stock

Source

Original product source