PF-4800567 hydrochloride is a potent and selective inhibitor of? casein kinase?1? (CK1?) , with an? IC 50 ?of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM). PF-4800567 hydrochloride is useful in probing unique roles between these two kinases in multiple signaling pathways.
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