ML372

Overview

ML372 inhibits survival motor neuron ( SMN ) protein ubiquitination, increases SMN protein stability without affecting mRNA expression. ML372 improves spinal muscular atrophy (SMA) in mice. ML372 is brain penetrant and has a reasonable exposure and half-life in vivo.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-124713
• CAS No.: 1331745-61-9
• Molecular Formula: C18H20N2O4S
• Molecular Weight: 360.43
• Purity: 99.17%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution
• Availability: In-stock

Source

Original product source