hSMG-1 inhibitor 11j

Overview

hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1 , with an IC 50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR ( IC 50 =50 nM), PI3Kα/γ ( IC 50 =92/60 nM) and CDK1/CDK2 ( IC 50 =32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > GSK-3 | Products > Signaling Pathways > CDK

Product Information

• Catalog No.: HY-124719
• CAS No.: 1402452-15-6
• Molecular Formula: C27H28ClN7O3S
• Molecular Weight: 566.07
• Purity: 99.82%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 6 mg/mL (10.60 mM); Clear solution
• Availability: In-stock

Source

Original product source