Poloppin

Overview

Poloppin is a potent, cell penetrant inhibitor of the mitotic Polo-like kinase (PLK) ( IC 50 =26.9 μM) and prevents the protein-protein interaction via the Polo-box domain (PBD) ( K d = 29.5 μM). Poloppin selectively kills cells expressing mutant KRAS, enhancing death in mitosis . Poloppin is used for the study of KRAS-mutant cancers as single agents, or in combination with c-MET inhibitors.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Autophagy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Polo-like Kinase (PLK) | Products > Signaling Pathways > Mitosis | Products > Signaling Pathways > Autophagy

Product Information

• Catalog No.: HY-124761
• CAS No.: 683808-78-8
• Molecular Formula: C20H15BrF3NO2
• Molecular Weight: 438.24
• Purity: 99.40%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source