7DG

Overview

7DG (7-Desacetoxy-6,7-dehydrogedunin) is a PKR inhibitor, P2X7 purinergic receptor inhibitor, and skin-lightening agent. 7DG binds outside the ATP -catalytic domain of PKR , blocks the kinase activity-independent protein-protein interactions of PKR , inhibits the phosphorylation and activity of PKR , disrupts ASC assembly and caspase-1 activation, and suppresses the activation of the NLRP1 inflammasome. 7DG inhibits pyroptosis , suppresses the ATP-P2X7 signaling pathway, and abolishes ATP-induced increases in the expression levels of MITF , tyrosinase , PMEL/gp100 , and melanin content. 7DG exerts skin-lightening effects in cultured skin in vitro. 7DG can be used in research related to chronic obstructive pulmonary disease, gout, type 2 diabetes, Alzheimer's disease, and hyperpigmentary skin disorders.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Chronic Disease and Inflammation | Products > Disease Areas > Respiratory Inflammation | Products > Disease Areas > Arthritis | Products > Disease Areas > Purine Metabolism | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Alzheimer's Disease | Products > Disease Areas > Chronic Obstructive Pulmonary Disease | Products > Disease Areas > Gout | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > P2X Receptor | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > Pyroptosis | Products > Signaling Pathways > Tyrosinase | Products > Signaling Pathways > PERK | Products > Signaling Pathways > Prokineticin Receptor

Product Information

• Catalog No.: HY-124857
• CAS No.: 26927-01-5
• Molecular Formula: C26H30O5
• Molecular Weight: 422.51
• Purity: 98%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source