2BAct

Overview

2BAct is a highly selective, orally active, and CNS-penetrant eIF2B ( eukaryotic initiation factor 2B) activator with an EC 50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB trans-isomer ( HY-12495 ).

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Eukaryotic Initiation Factor (eIF)

Product Information

• Catalog No.: HY-125021
• CAS No.: 2143542-28-1
• Molecular Formula: C19H16ClF3N4O3
• Molecular Weight: 440.80
• Purity: 99.77%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 5 mg/mL (11.34 mM); Clear solution
• Availability: In-stock

Source

Original product source