Dasminapant

Overview

Dasminapant (APG-1387), a bivalent SMAC mimetic and an IAP antagonist, blocks the activity of IAPs family proteins ( XIAP , cIAP-1 , cIAP-2 , and ML-IAP). Dasminapant induces degradation of cIAP-1 and XIAP proteins, as well as caspase-3 activation and PARP cleavage, which leads to apoptosis . Dasminapant can be used for the research of hepatocellular carcinoma, ovarian cancer , and nasopharyngeal carcinoma.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > IAP | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-125593
• CAS No.: 1570231-89-8
• Molecular Formula: C60H72N10O10S2
• Molecular Weight: 1157.40
• Purity: 99.70%
• Storage: -20°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Solubility: ≥ 2.5 mg/mL (2.16 mM); Clear solution
• Availability: In-stock

Source

Original product source