(S)-PNU-282987 hydrochloride is an isoform of PNU-282987 ( HY-12560 ). PNU-282987 (free base) is a potent α7 nicotinic acetylcholine receptor ( nAChR ) agonist with an EC 50 of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT 3 receptor with an IC 50 of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems.
Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > nAChR | Products > Signaling Pathways > 5-HT Receptor
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