Syn-516 is an inhibitor of α-synuclein ( α-Syn ). Syn-516 targets the 5' untranslated region (5'UTR) of α-Syn mRNA , with an IC 50 value of 1.8 μM, thereby inhibiting the translation process of α-Syn. Syn-516 improves motor dysfunction and colonic motility abnormalities associated with α-Syn overexpression in mouse models. α-Syn can be used to study diseases such as Parkinson's disease and Lewy body dementia.
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