BRL 22321 free base is a stabilizer with similar mast cell stabilizing activity to Cromolyn sodium ( HY-B0320A ) and also has some smooth muscle relaxant activity. BRL 22321 free base is more potent than Cromolyn sodium ( HY-B0320A ) in inhibiting rat passive cutaneous and peritoneal anaphylaxis and antigen-induced histamine release from passively sensitized rat peritoneal cells.
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