PRMT5 IN-1, a hemiaminal, is a potent, selective protein arginine methyltransferase 5 ( PRMT5 ) inhibitor with an IC 50 of 11 nM for PRMT5/MEP50. PRMT5 IN-1 can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions.
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