BRL-44408

Overview

BRL-44408 is a selective, blood-brain barrier-permeable α 2 A-adrenergic receptor antagonist with a K i value of 8.56 nM against human targets. BRL-44408 exhibits activities such as antidepressant, analgesic effects and attenuation of sepsis-induced acute lung injury by regulating the release of neurotransmitters such as norepinephrine and dopamine, or inhibiting signaling pathways including ERK1/2 , p38MAPK and p65 . BRL-44408 can be used in studies related to acute respiratory distress syndrome, depression and visceral pain.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Adrenergic Receptor | Products > Signaling Pathways > ERK | Products > Signaling Pathways > Dopamine Receptor | Products > Signaling Pathways > p38 MAPK

Product Information

• Catalog No.: HY-12716
• CAS No.: 118343-19-4
• Molecular Formula: C13H17N3
• Molecular Weight: 215.29
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source