CARM1-IN-1 hydrochloride

Overview

CARM1-IN-1 (compound 7g) hydrochloride is a highly potent and selective inhibitor of CARM1 (IC 50 =8.6 μM, CARM1/PABP1), with low inhibitory activity against PRMT1 and SET7 (IC 50 >667 μM). CARM1-IN-1 hydrochloride inhibits the methylation activity of CARM1 and the methylation levels of different substrates, such as PABP1, CA150, SmB, and H3. CARM1-IN-1 hydrochloride also inhibits the promoter activity of prostate-specific antigen (PSA) without significant cytotoxicity.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Histone Methyltransferase

Product Information

• Catalog No.: HY-12759A
• CAS No.: 2070018-31-2
• Molecular Formula: C26H22Br2ClNO3
• Molecular Weight: 591.72
• Purity: 95.17%
• Storage: 4°C, sealed storage, away from moisture * The compound is unstable in solutions, freshly prepared is recommended.
• Solubility: ≥ 2.5 mg/mL (4.22 mM); Clear solution
• Availability: In-stock

Source

Original product source