Losartan-d 4 (carboxylic acid)

Overview

Losartan-d 4 carboxylic acid (E-3174-d 4 ) is the deuterium labeled Losartan Carboxylic Acid ( HY-12765 ). Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The K i values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Endocrinology | Products > Research Areas > Cardiovascular Disease | Products > Research Areas > Cancer | Products > Signaling Pathways > Angiotensin Receptor

Product Information

• Catalog No.: HY-12765S
• CAS No.: 1246820-62-1
• Molecular Formula: C22H17D4ClN6O2
• Molecular Weight: 440.92
• Purity: 98.09%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source