Vps34-IN-1

Overview

Vps34-IN-1 is a potent and selective inhibitor of class III Vps34 PI3K . Vps34-IN-1 inhibits phosphorylation of PtdIns by recombinant insect cell expressed Vps34-Vps15 complex with an IC 50 of ~25 nM. Vps34-IN-1 can suppress SGK3 activation by reducing PtdIns(3)P levels via lowering phosphorylation of T-loop and hydrophobic motifs. Vps34-IN-1 modulates autophagy .

Application

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Product Information

• Catalog No.: HY-12795
• CAS No.: 1383716-33-3
• Molecular Formula: C21H24ClN7O
• Molecular Weight: 425.91
• Purity: 99.79%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months
• Solubility: ≥ 2.5 mg/mL (5.87 mM); Clear solution
• Availability: In-stock

Source

Original product source